Especially for people of our generation, who really celebrated certain attitudes - the outsider, the loner - it can have a real impact on the art when they realize, I have friends, I'm married, or I have kids. That's certainly happened to me.
Look, there's no denying that comics have moved dramatically into the mainstream in North American culture in the last 10 years, and for someone like me who's always tried to make a living at it, it's been great, I'm very grateful for it. But at the same time, it's not a subculture-y thing anymore; it's something that's in the New York Times and the New Yorker.
I think a lot of the bells and whistles that become available to you would be impossible to resist for some people, so it's just never going to be a real stand-in version of your comic. People will have to take advantage of the ability to have sound, or zoom in and out, whatever it is.
Just in terms of being able to be a professional artist, but also it's nice to not have to dread introductions. "What you do for a living?" It used to be easier just to tell people that I was a magazine illustrator than try to explain that I did comics, but not the kind of comics that they were used to, and no, it's not pornography, etc. And now people even of our parents' generation are familiar with the term "graphic novel," which is kind of amazing.